Fatigue Scales and Chronic Fatigue Syndrome: Issues of Sensitivity and Specificity


  • Leonard Jason
  • Jason Meredyth Evans
  • Molly Brown
  • Nicole Porter
  • Abigail Brown
  • Jessica Hunnell
  • Valerie Anderson
  • Athena Lerch




chronic fatigue syndrome, fatigue, fatigue scales, sensitivity and specificity


Few studies have explored issues of sensitivity and specificity for using the fatigue construct to identify patients meeting chronic fatigue syndrome (CFS) criteria. In this article, we examine the sensitivity and specificity of several fatigue scales that have attempted to define severe fatigue within CFS. Using Receiver Operating Characteristic (ROC) curve analysis, we found most scales and sub-scales had either significant specificity and/or sensitivity problems. However, the post-exertional subscale of the ME/CFS Fatigue Types Questionnaire (Jason, Jessen, et al., 2009) was the most promising in terms of specificity and sensitivity. Among the more traditional fatigue scales, Krupp, LaRocca, Muir-Nash, and Steinberg’s (1989) Fatigue Severity Scale had the best ability to differentiate CFS from healthy controls. Selecting questions, scales and cut off points to measure fatigue must be done with extreme care in order to successfully identify CFS cases.




How to Cite

Jason, L., Evans, J. M., Brown, M., Porter, N., Brown, A., Hunnell, J., … Lerch, A. (2011). Fatigue Scales and Chronic Fatigue Syndrome: Issues of Sensitivity and Specificity. Disability Studies Quarterly, 31(1). https://doi.org/10.18061/dsq.v31i1.1375